By M. J. Narasimhan, Stacey B. Day (auth.), Stacey B. Day (eds.)
Late in summer season 1973, the Bell Museum of Pathology of the collage of Minnesota scientific university, held a 3 day symposium to debate a number of the organic features of trauma ailment. The assembly used to be meant to be a coatribution to the research of trauma by means of putting emphasis upon some of the simple biologic concerns relating to trauma accidents. It was once additionally was hoping to install concentration views from which positive interplay among uncomplicated study scientists and practising clinicians may circulate. it's our trust that it really is via such interdisciplinary exchanges that clever development and new advancements will take place. furthermore we think that the coed physique and the training general practitioner can both proportion this medical backdrop, and in a feeling needs to so take part, for in a technological society trauma accidents face the possibility of a nearly exponential raise in numbers, decade to decade. With those perspectives in brain we introduced jointly biologists, biophysicists, biochemists, pathologists, physicians and surgeons, with a view to construct a brand new bridge of collaborative realizing among unrelated disciplines, which, long ago, have charac teristically infrequently inter-related, one to the opposite. there have been no challenging and speedy ideas set within the number of issues. no longer unusually, consequently, this system built into one in every of varied and noteworthy scope and breadth. Papers for dialogue various from the biochemistry of collagen metabolism to positive aspects of trauma attribute of aviation and air trauma accidents.
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Additional info for Trauma: Clinical and Biological Aspects
33. J. : Collagen proline hydroxylase in wound healing, granuloma formation, scurvy and growth. Science 157:927, 1967. 34. : Collagen synthesis and preliminary wounding. Brit. J. Surg. 51:149, 1964. 35. : Some aspects of fibrogenesis during the healing of primary and secondary wounds. Surg. Gyn. Obst. 115: 408, 1962. 36. : Inter- and intramolecular bonding in collagen of healing wounds by insertion of methylene and amide crosslinks into scar tissue. Ann. Surg. 163:1, 1966. 37. : Some studies on the effect of B-amino-propionitrile on collagen in healing wounds.
Protocollagen proline hydroxylase in normal liver and in hepatic fibrosis. Gastroenterology 56:744, 1969. 49. : Protocollagen proline hydroxylase activity in the skin of normal subjects and of patients with scleroderma. Scand. J. Clin. Lab. Invest. 23:241, 1969. 50. : healing. 51. Weeks, P. : Functional organization of collagen subunits. Surg. Forum 19:59, 1968. 52. : The late phases of wound healing: Histological and ultrastructural studies of collagen and elastic-tissue formation. J. Path. 102:61, 1970.
The data to be summarized have been selected mainly from recent studies on "normal" wound healing. Unfortunately, few facts are available concerning collagen metabolism in healing complications such as keloids. COURSE OF WOUND HEALING Clinical and experimental injury to the skin may be produced in several ways: mechanical force, skin incision, skin excision, burns, application of caustic substances, radiation, etc. Incised wounds may be readily inflicted in a uniform manner and, thus, have been the 31 32 QUENTIN T.