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1992). A significant decrease in nasal mucus flow was seen in 15 healthy subjects at 5 and 25 ppm sulfur dioxide (Anderson et al. 1974). Reduced bronchial clearance was observed at 5 ppm (Wolff et al. 1986). Exercise increased the rate of bronchial clearance (Wolff et al. 1986). Increased airway resistance during rest was observed in 7 healthy subjects exposed to 4–6 ppm sulfur dioxide in a body plethysmograph for 10 minutes (Nadel et al. 1965). When 11 healthy subjects were exposed mouth only to 5 ppm sulfur dioxide for 10–30 minutes, increased flow resistance was noted (Frank et al.

SULFUR DIOXIDE 2. 25 ppm sulfur dioxide (Myers et al. 1986a, 1986b). 5 ppm (Jorres and Magnussen 1990; Koenig et al. 1990). Bronchoconstrictive responses to sulfur dioxide are highly variable among individual asthmatics (Horstman et al. 1986). In some studies, asthmatics were preselected for sensitivity to sulfur dioxide and this may explain the range of sulfur dioxide–induced responses obtained by different investigators. In addition to exercise, sulfur dioxide–induced bronchoconstriction can be increased by cold or dry air (Sheppard et al.

25 ppm through a mouthpiece (Sheppard et al. 1981). 1 ppm sulfur dioxide through a mouthpiece for 10 minutes (Sheppard et al. 1981). 5 ppm sulfur dioxide. 25 ppm, the difference between baseline specific airway resistance and specific airway resistance ()SRaw) after inhalation of sulfur dioxide was approximately 5 L×cm H20/L/s (units of SRaw). 5 ppm, the )SRaw exceeded 15 L×cm H20/L/s. 25 ppm sulfur dioxide have been reported by other investigators. In a chamber study of moderately exercising asthmatics, the concentration of sulfur dioxide required to produce an increase in airway resistance 100% greater than the response to clean air [designated as PC(SO2)] has been determined (Horstman et al.

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