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Extra resources for Toxicological profiles - Polycyclic Aromatic Hydrocarbons

Sample text

Therefore, the LOAEL of 10 mg/kg/day noted in the F 1 progeny discussed above is not presented in Table 2-2. Higher doses produced total sterility. This study provides good evidence for the occurrence of developmental effects following in utero exposure to benzo[a]pyrene. The effect of genetic differences in metabolism of orally administered benzo[a]pyrene on in utero toxicity and teratogenicity was evaluated in mice that either metabolize benzo[a]pyrene readily (Ah-responsive) or not (Ah-nonresponsive) (Legraverend et al.

Male and female mice exposed to 0, 125, 250, or 500 mg/kg/day fluorene by gavage for 13 weeks showed no evidence of tumorigenesis at necropsy (EPA 1989e). Chronic-Duration Exposure. 15 mg/kg until the animals were either moribund or dead (Brune et al. 1981).

2%). 25% in the diet administered for 15 days indicated adducts in the lung, liver, and spleen of all animals. Adduct patterns were similar, but quantitative differences were observed between coal tar samples and tissue sites. The highest adduct levels were detected in lung DNA. Adduct formation in animals fed the benzo[a]pyrene diet, could not account for the differences in the adduct levels observed in animals given the mixtures. Also, adduct formation in animals fed the coal tar mixtures correlated with benzo[a]pyrene content in the coal tar, indicating the adducts arose from a variety of PAHs in the coal tar mixtures.

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