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1987; Friedman and Staub 1976; McFee et al. 1989). From this information, N -nitrosodiphenylamine does not appear to be genotoxic to intact animal systems. Data from in vitro studies using prokaryotic and eukaryotic organisms and cultured mammalian cells are presented in Table 2-3. The response has been negative for the majority of gene mutation studies. However, two Salmonella assays detected gene mutations after exposure to metabolically activated N-nitrosodiphenylamine (Khudoley et al. 1987; Zielenska and Guttenplan 1988).

1982). 28 mg/kg N-nitrosodiphenylamine and 50 µmol proline by gavage (Ohshima et al. 1982). The excretion of N-nitrosoproline was 15-fold higher than in the controls. Co-administration of thiocyanate had a catalytic effect, which resulted in a 58-fold increase in the urinary levels of N -nitrosoproline. N-Nitrosodiphenylamine can undergo reductive metabolism by liver aldehyde oxidase under anaerobic conditions (Tatsumi et al. 1983). Guinea pigs received oral dosages (200 mg/kg) of N -nitrosodiphenylamine.

Guinea pigs received oral dosages (200 mg/kg) of N -nitrosodiphenylamine. Just before and 3 hours after administration of N-nitrosodiphenylamine, the guinea pigs were treated with oral dosages (50 mg/kg) of acetaldehyde (an electron donor). Acetaldehyde diphenylhydrazone was identified as a plasma metabolite. 3 Dermal Exposure No studies were located regarding metabolism of N-nitrosodiphenylamine in humans or animals after dermal exposure. 1 Inhalation Exposure No studies were located regarding excretion of N-nitrosodiphenylamine in humans or animals after inhalation exposure.

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