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By Syracuse Research Corporation

The ATSDR toxicological profile succinctly signify the toxicological and opposed wellbeing and fitness results details for the dangerous substance defined therein. the point of interest of the profiles is on wellbeing and fitness toxicological info; hence every one toxicological profile starts with a public healthiness assertion that describes, in nontechnical language, a substance's appropriate toxicological houses.

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Sample text

Since persons with severe asthma were excluded from the study, an uncertainty factor of 3 is needed to protect all sensitive individuals including children. Hessel et al. (1997) examined the pulmonary health effects of hydrogen sulfide exposure in a group of Canadian oil and gas workers. Exposure to hydrogen sulfide was assessed by questionnaire as was the occurrence of respiratory symptoms; in addition, smoking and occupational histories were conducted. Lung health was assessed via spirometric testing and by skin prick testing for six common antigens.

No treatment-related histopathological changes were detected in the kidneys of these animals and urinalysis findings were negative, indicating no renal effects due to hydrogen sulfide exposure. 5 ppm of hydrogen sulfide continuously for 17 days (Curtis et al. 1975). Endocrine Effects. No studies were located regarding endocrine effects in humans after inhalation exposure to hydrogen sulfide. 5, or 80 ppm hydrogen sulfide 6 hours/day, 5 days/week, for 90 days (CIIT 1983a, 1983b, 1983c). Dermal Effects.

1991 Cardio 22 23 75 M (cardiac arrhythmia; decreased heart rate) Rat (Fischer-344) 4 hr Resp 10 M (increased cellularity in nasal lavage fluid) Lopez et al. 1987 Rat (Fischer-344) 4 hr Resp 83 M (mild perivascular edema) Lopez et al. 1988a 2. HEALTH EFFECTS (bronchial obstruction in 2/10 asthmatics) HYDROGEN SULFIDE TABLE 2-1. 5 hr/d Cardio NOAEL (ppm) Less serious (ppm) Serious (ppm) 400 M 200 M 400 M (epiphora) Lopez et al. 1988b Lopez et al. 1988b 375 M 20 M (severe inflammation and necrosis of respiratory and olfactory epithelium) Reference (moderate to massive pulmonary edema) (eye irritation) Prior et al.

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