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A single 8-hour exposure to 5,900 ppm did not cause histopathological changes. Organ weights were not determined for the higher exposure concentration. The relative liver weight was significantly increased (p value not given) in guinea pigs and rats, but not dogs or quail, that were exposed to 260 ppm 6 hours/day, 5 days/week for 6 weeks (Weeks et al. 1979). Since the increase in liver weight was not accompanied by any histological abnormalities, it is classified as a NOAEL rather than a LOAEL in Table 2-1 and Figure 2-1.

Regenerative tubular epithelium was visible and degeneration of the tubular epithelium occurred at the junction of the cortex and the medulla. Hyaline casts were present in the tubules, and fibrosis, calcium deposition, and inflammatory cells were noted in the kidney tissues. Male rats are sensitive to renal tubular nephropathy after exposure to hexachloroethane. The lesions observed are characteristic of hyaline droplet nephropathy. They are most likely the result of hexachloroethane or one of its metabolites binding to the excretory protein "2µ-globulin, altering its kidney transport, and leading to the formation of hyaline droplets.

1979). In the intermediate-duration exposure category, doses of 750 mg/kg/day or less were tested in rats (Gorzinski et al. 1985; NTP 1989) while for chronic exposures, doses of 20 mg/kg/day or less were given to male rats and 160 mg/kg/day or less were given to female rats (NTP 1989). No studies were identified that evaluated a wide range of immunological parameters; therefore, there is no reliable LOAEL or NOAEL for this end point. 4 Neurological Effects No studies were located regarding neurological effects in humans after oral exposure to hexachloroethane.

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