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All mice exposed at 175 mg/kg/day died, suggesting a steep dose-response relationship between the mid- and high-treatment doses (Borzelleca et al. 1985a). In repeated-dose studies of 2,4-DCP in corn oil, 4 out of 34 pregnant Fischer-344 rats treated by gavage at 750 mg/kg/day on gestation days 6–15 died (Rodwell et al. 1989), while all nonpregnant rats treated with 2,000 mg/kg/day in the diet for 14 days survived (NTP 1989). Although pregnant rats may be more susceptible, the difference in effect may also be a result of differences in the rate of exposure between gavage and dietary dosing.

8 Cancer A number of investigators have studied the potential association between chlorophenol-based pesticide production and carcinogenicity (Eriksson et al. 1981, 1990; Hardell et al. 1981; Hoar et al. 1986; Honchar and Halperin 1981; Kogevinas et al. 1992; Lynge 1985; Smith et al. 1984; Woods et al. 1987). Reports from Sweden indicate significantly increased relative risk ratios for soft tissue sarcomas (STS) and/or non-Hodgkin's lymphomas (NHLs) in exposed workers (Eriksson et al. 1981, 1990; Hardell et al.

In both studies the 2,3,4,6-TeCP was given in olive oil. The LD50 values and all reliable LOAEL values for death in each species and duration category are recorded in Table 2-2 and plotted in Figure 2-2. 2 Systemic Effects The highest NOAEL values and all reliable LOAEL values for systemic effects in each species and duration category for oral exposures to chlorophenols are recorded in Table 2-2 and plotted in Figure 2-2. Respiratory Effects. No studies were located regarding respiratory effects in humans after oral exposure to any of the eight chlorophenols discussed in this profile.

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