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4 ppm and above, and followed a concentration response curve. 3 and 100 ppm, new osseous spicules were present at the beginning of the first endoturbinate, while at 271 ppm, the width of the new bone was almost doubled compared to controls. The Bowman’s glands were markedly reduced in size. Cytochrome P-450-2E1 staining was most prominent in the cytoplasm of olfactory epithelial sustentacular cells and in the acinar cells of Bowman’s glands in control animals. In general, increasing the chloroform concentration tended to decrease the amount of P-450 staining in exposed animals.

1979). In males, groups of 10–12 male rats (strain not reported) were exposed to 0, 25, 50, or 85 ppm chloroform for 6 months. Adjusted testicular weights in the 50 and 85 ppm groups were greater than those of their respective controls, but were not different from those of other control groups within the same colony. Additionally, no histological changes were noted in testicular tissues of treated animals. The significant increase in testes weights reported in this study was considered to be spurious not likely a direct effect of chloroform exposure (Torkelson et al.

Decreased survival rates were also observed in male mice exposed to 250 mg/kg/day chloroform for 14 days, but not in mice exposed to 100 mg/kg/day. Female mice, however, survived 500 mg/kg/day chloroform treatment (Gulati et al. 1988). Increased mortality was noted in 5 of 12 male mice exposed to 277 mg/kg/day in corn oil by gavage for 4 days (Larson et al. 1994d). Pregnant animals may be more susceptible to chloroform lethality. Increased mortality was observed in pregnant rats exposed to 516 mg/kg/day.

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