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Extra resources for Toxicological profiles - 4,4'-methylenebis-(2-chloroaniline) (mboca)

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In another acute study, radiolabeled MBOCA was administered by gavage to rats by gavage (Morton et al. 1988). Forty-eight hours later, 64-87% of the administered radioactivity was recovered in the urine and feces. 5-3 times the radioactivity of the urine. These results are consistent with previous reports that in rats MBOCA is extensively metabolized and rapidly excreted. 3 Dermal Exposure Although no studies were located regarding distribution in humans after dermal exposure to MBOCA, it appears that it is rapidly eliminated from the body following dermal exposure.

Studies with intravenous administration of MBOCA in the dog found that the major route of excretion 14 was through the urine (Manis et al. 1984). Within 24 hours after intravenous injection of C-MBOCA, 46% of the dose had been excreted in the urine and 32% in the bile, accounting for 78% of the total dose. This indicates that often substantial differences occur between species and that route of exposure determines the route of elimination of MBOCA. In an attempt to use thioether as a potential urinary indicator for MBOCA exposure, male Wistar rats were exposed intraperitoneally to 125 or 250 mg/kg/day of MBOCA in peanut oil (vehicle) daily for 5 days, while the control received peanut oil only (Edwards and Priestly 1992).

1989). These results indicate that there are species differences in the oxidation of MBOCA. The major metabolite in the guinea pig liver microsome system was N-hydroxy MBOCA, while dog microsomes oxidized MBOCA to the o-hydroxylated metabolite with significant amounts of hydroxylamine. In the rat liver microsome system, other polar metabolites were predominant, while there were fewer N- and o-hydroxylated MBOCA derivatives (Chen et al. 1989). 3 Dermal Exposure MBOCA metabolites were investigated in urine samples from workers occupationally exposed to MBOCA (Cocker et al.

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