Download The Principles of Clinical Cytogenetics by Steven L. Gersen Ph.D. (auth.), Steven L. Gersen PhD, Martha PDF

By Steven L. Gersen Ph.D. (auth.), Steven L. Gersen PhD, Martha B. Keagle MEd (eds.)

Show description

Read Online or Download The Principles of Clinical Cytogenetics PDF

Best clinical books

Multiple Drug Resistance in Cancer: Cellular, Molecular and Clinical Approaches

This ebook is an up to date evaluation of present wisdom within the box of a number of drug resistance in human melanoma. The literature as much as the center of 1993 is surveyed in professional chapters written through various specialists. themes lined contain the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; substitute shipping proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; mobile versions for MDR in good tumours and haemopoietic tumours; immunochemical and molecular organic thoughts for detection of MDR-related gene expression; and medical and pharmacological concepts to bypass resistance.

Clinical Transplantation: Current Practice and Future Prospects

This quantity has been written in particular for the working towards clinician. All points of scientific transplantation have accelerated greatly in recent times, yet a number of the medical professionals concerned have acquired very little college in immunology as scientific scholars. many of the chapters, written by means of physicians, surgeons, pathologists and immunologists current the various at present very important concerns in transplantation and exhibit simple project of immunology is now crucial in lots of parts of scientific perform.

Alzheimer’s Dementia: Dilemmas in Clinical Research

The nationwide Institute on getting older (NIA) has traditionally been enthusiastic about the safety of human topics. In July 1977, the NIA subsidized a gathering to replace and complement consultant­ traces for safeguarding these engaging in Federal examine seasoned­ jects. even supposing the elemental guidance have been in impression in view that 1966, it were ignored to incorporate the aged as a susceptible inhabitants.

Bone Metastases: A translational and Clinical Approach

The second one variation of this booklet serves either as an introductory and reference booklet targeting the sphere of metastatic bone sickness. that includes contributions from specialists within the box, this quantity describes the molecular and mobile mechanisms keen on the formation of bone metastases, offers the more moderen advances made within the realizing of the medical photograph and indicators of sufferers, analyses the position of bone markers in examine and scientific perform and bargains with all features of imaging modalities utilized for the detection and assessment of bone metastases.

Additional resources for The Principles of Clinical Cytogenetics

Example text

This stage lasts only 1-2 h in most mammalian cells. Mitosis is the process by which cells reproduce themselves, creating two daughter cells that are genetically identical to one another and to the original parent cello Mitosis is itself divided into stages (Fig. 10). 24 Martha Keagle and Judith Brown MITOSIS Prophase Chromosomes are at their greatest elongation and are not visible as discrete structures under the light microscope during interphase. During prophase, chromosomes begin to coil, become more condensed, and begin to become visible as discrete structures.

All 46 chromosomes are matemally derived. NEOPLASIA The basic roles for using the nomenclature apply when describing the karyotypes associated with cancer. However, special situations, requiring additional guidelines, may arise in these cases. Therefore special ISCN definitions and roles have been devised for use with neoplasia. Clones A clone is defined as two cells that share the same abnormality or abnormalities, unless the change involves loss of a chromosome, in which case three such cells are required (due to the possibility of coincidental random chromosome loss).

2 f" •• ~ - n •• •• ~n~ ... i i •• .. H u~: • • ~" 13 o ~ "' .. ' 14 .. r. n", II 9 u H 'ii 17 18 ;; :. •• ••. _~ e~ 21 r .... "M~ '- '22 X ~ Y Fig. 4. A composite karyotype of G-banded chromosomes (left) along with the corresponding 1971 Paris Conference ideograms (right). some abnormalities in a more meaningful way. Other conferences then followed, with the latest held in Memphis in 1994. Descriptions of human chromosomes and their abnormalities utilize aseries of symbols and abbreviations. A partial list of recommended symbols and abbreviations in ISCN 1995 appears in Table 3.

Download PDF sample

Rated 4.65 of 5 – based on 11 votes