By Hermann Cuntz, Michiel W.H. Remme, Benjamin Torben-Nielsen
Neuronal dendritic timber are complicated buildings that endow the mobilephone with strong computing services and make allowance for prime neural interconnectivity. learning the functionality of dendritic buildings has an extended culture in theoretical neuroscience, beginning with the pioneering paintings via Wilfrid Rall within the Fifties. fresh advances in experimental concepts let us learn dendrites with a brand new viewpoint and in larger element. The target of this quantity is to supply a résumé of the cutting-edge in experimental, computational, and mathematical investigations into the services of dendrites in quite a few neural systems.
The booklet first appears at morphological houses of dendrites and summarizes the ways to degree dendrite morphology quantitatively and to really generate man made dendrite morphologies in desktop versions. This morphological characterization levels from the learn of fractal rules to explain dendrite topologies, to the implications of optimization rules for dendrite form. person methods are accumulated to review the elements of dendrite form that relate on to underlying circuit constraints and computation.
The moment major subject makes a speciality of how dendrites give a contribution to the computations that neurons practice. What position do dendritic morphology and the distributions of synapses and membrane houses over the dendritic tree have in picking out the output of a neuron based on its enter? quite a lot of experiences is introduced jointly, with issues starting from common to system-specific phenomena—some having a powerful experimental part, and others being totally theoretical. The experiences come from many various neural structures and animal species starting from invertebrates to mammals. With this vast concentration, an summary is given of the range of mechanisms that dendrites can hire to form neural computations.
Read Online or Download The Computing Dendrite: From Structure to Function PDF
Similar machine theory books
Are you accustomed to the IEEE floating aspect mathematics usual? do you want to appreciate it higher? This e-book provides a huge evaluate of numerical computing, in a historic context, with a unique specialise in the IEEE usual for binary floating aspect mathematics. Key rules are constructed step-by-step, taking the reader from floating element illustration, thoroughly rounded mathematics, and the IEEE philosophy on exceptions, to an figuring out of the an important strategies of conditioning and balance, defined in an easy but rigorous context.
This publication is worried with very important difficulties of sturdy (stable) statistical pat tern attractiveness while hypothetical version assumptions approximately experimental information are violated (disturbed). development reputation thought is the sphere of utilized arithmetic within which prin ciples and strategies are developed for class and id of gadgets, phenomena, approaches, events, and indications, i.
This publication offers an important step in the direction of bridging the components of Boolean satisfiability and constraint pride through answering the query why SAT-solvers are effective on yes sessions of CSP circumstances that are difficult to unravel for normal constraint solvers. the writer additionally offers theoretical purposes for selecting a specific SAT encoding for a number of vital periods of CSP cases.
A clean examine the query of randomness was once taken within the conception of computing: A distribution is pseudorandom if it can't be exotic from the uniform distribution by means of any effective process. This paradigm, initially associating effective methods with polynomial-time algorithms, has been utilized with admire to a number of average sessions of distinguishing strategies.
- Machine Learning Applications In Software Engineering (Series on Software Engineering and Knowledge Engineering)
- Artificial Intelligence and Symbolic Computation: 12th International Conference, AISC 2014, Seville, Spain, December 11-13, 2014. Proceedings
- Directed Algebraic Topology and Concurrency
- Discrete Mathematics
- Computation, Logic, Philosophy: A Collection of Essays
Extra info for The Computing Dendrite: From Structure to Function
Brain Res 576:152–156 Oberlaender M, Boudewijns ZSRM, Kleele T et al (2011) Three-dimensional axon morphologies of individual layer 5 neurons indicate cell type-specific intracortical pathways for whisker motion and touch. Proc Natl Acad Sci USA 108:4188–4193 Oberlaender M, De Kock CPJ, Bruno RM et al (2012) Cell type-specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex. Cereb Cortex 22:2375–2391 Peng H, Ruan Z, Long F et al (2010) V3D enables real-time 3D visualization and quantitative analysis of large-scale biological image data sets.
Cuntz Gleeson P, Crook S, Cannon RC et al (2010) NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail. PLoS Comput Biol 6:e1000815 Helmstaedter M, Briggman KL, Denk W (2011) High-accuracy neurite reconstruction for high-throughput neuroanatomy. Nat Neurosci 14:1081–1088 Hentschel HG, Fine A (1996) Diffusion-regulated control of cellular dendritic morphogenesis. Proc Biol Sci 263:1–8 Hepburn I, Chen W, Wils S, De Schutter E (2012) STEPS: efficient simulation of stochastic reaction—diffusion models in realistic morphologies.
2011). Fascin is another downstream effector of Cut. Fascin is a conserved actin-bundling protein, typically associated with filopodia particularly in motile cells, including fly blood cells and metastasizing cancer cells (Zanet et al. 2009; Machesky and Li 2010). In da neurons, it is a specific marker of the short straight terminal branchlets of class III neurons and is required for their formation (Nagel et al. 2012). Fascin is not detected in the dendrites of low-Cut class I neurons. Nonetheless, when Cut is overexpressed in class I neurons, their dendrites become decorated with class III neuron-type short straight branchlets that are now marked by the presence of fascin.