Download Recent Advances in Clinical Trial Design and Analysis by David L. DeMets, Gordon Lan (auth.), Peter F. Thall Ph.D. PDF

By David L. DeMets, Gordon Lan (auth.), Peter F. Thall Ph.D. (eds.)

Clinical trials have reasons -- to regard the sufferers within the trial, and to acquire details which raises our realizing of the affliction and particularly how sufferers reply to remedy. Statistical layout offers a way to accomplish either those goals, whereas statistical facts research offers equipment for extracting worthwhile info from the trial facts.
fresh advances in statistical computing have enabled statisticians to enforce very swiftly a extensive array of tools which formerly have been both impractical or very unlikely. Biostatisticians are actually in a position to offer a lot larger help to clinical researchers operating in either medical and laboratory settings. As our collective toolkit of strategies for interpreting info has grown, it has develop into more and more tough for biostatisticians to maintain with the entire advancements in our personal box. Recent Advances in scientific Trial layout and Analysis brings jointly biostatisticians doing state-of-the-art learn and explains the various newer advancements in biostatistics to clinicians and scientists who paintings in medical trials.

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Lan KKG, Lachin J (1990). Implementation of group sequentiallogrank tests in a maximum duration trial. Biometrics 46:759-770. 54. Sellke T, Siegmund D (1983). Sequential analysis of the proportional hazards model. Biometrika 70:315-326. 55. Kim K, Tsiatis AA (1990). Study duration for clinical trials with survival response and early stopping rule. Biometrics 46:81-92. 56. Kim K (1992). Study duration for group sequential clinical trials with censored survival data adjusting for stratification. Stat Med 11:1477-1488.

Effects of assumption violations on type I error rate in group sequential monitoring. Biometrics 48:1131-1143. 46. Kim K, DeMets DL (1992). Sample size determination for group sequential clinical trials with immediate response. Stat Med 11:1391-1399. 47. Fleming TR, Harrington DP (1991). Counting Processes and Survival Analysis. New York: Wiley. 48. Tarone R, Ware J (1978). On distribution free tests for equality of survival distributions. Biometrika 64:167-179. 49. Gail MH, DeMets DL, Siud EV (1992).

Jennison C, Turnbull BW (1989). Interim analyses: The repeated confidence interval approach. J R Stat Soc B 51:305-361. 69. DeMets DL, Lan KKG (1989). Discussion of: Interim analyses: The repeated confidence interval approach by C. W. Turnbull. J R Stat Soc B 51:362. 70. Fleming TR, Watelet LF (1989). Approaches to monitoring clinical trial. J Nat! Cancer Inst 81(3): 188-193. 71. Fleming TR (1990). Evaluation of active control trials in AIDS. J AIDS 3 (Suppl):S82-S87. 72. Fleming TR (1978). Treatment evaluation in active control studies.

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