Download Protein – Protein Interaction by Hongtao Guan, Endre Kiss-Toth (auth.), Meike Werther, Harald PDF

By Hongtao Guan, Endre Kiss-Toth (auth.), Meike Werther, Harald Seitz (eds.)

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Cardiac Excitation-Contraction Coupling . . . Ca2+ Regulatory Mechanisms . . . . . . Mathematical Models for Cardiac Systems Biology Integrative Systems Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Quantification for Functional Analysis . . . Mathematical Modeling . . . . . . . Sensitivity Analysis in Systems Biology . . . Quantification of Functional Regulatory Effects . . . .

Quantitatively, 92% of the cytosolic Ca2+ is removed by SERCA, 7% by NCX, and 1% by PMCA and mitochondria [6]. However, during heart failure in many animal models including humans and rabbits, the functional expression and activity of these Ca2+ regulatory mechanisms is significantly altered [8]. 2 Ca2+ Regulatory Mechanisms The intracellular Ca2+ dynamics is regulated by a variety of Ca2+ regulatory mechanisms. In particular, LTCC, RyR, SERCA and NCX are known to play a central role [9, 10] and we call these the key Ca2+ regulatory mechanisms.

Proc Natl Acad Sci USA 93:10315–10320 82. Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ (2004) Activation of apoptosis in vivo by a hydrocarbonstapled BH3 helix. Science 305:1466–1470 83. Wasinger VC, Cordwell SJ, Cerpa-Poljak A, Yan JX, Gooley AA, Wilkins MR, Duncan MW, Harris R, Williams KL, Humphery-Smith I (1995) Progress with geneproduct mapping of the Mollicutes: Mycoplasma genitalium. Electrophoresis 16:1090– 1094 84. Woycechowsky KJ, Vamvaca K, Hilvert D (2007) Novel enzymes through design and evolution.

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