Download Protein Kinase C Protocols by Alexandra C. Newton PDF

By Alexandra C. Newton

The 1st compilation of vintage and rising laboratory ideas for the examine of the biochemistry and telephone biology of protein kinase C (PKC). defined in step by step element, those equipment might be simply used to discover the constitution, functionality, law, subcellular localization, and macromolecular interactions of protein kinase C.. every one protocol is brought within the context of PKC functionality and legislation and includes many notes on how top to house the issues that can happen. finished and authoritative, Protein Kinase C Protocols is a well timed compilation of biophysical, biochemical, mobile organic, and molecular organic ways that brings protein kinase C study into any laboratory drawn to learning it.

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Et al. (2002) Stretch-induced retinal vascualr endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-ζ but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways. J. Biol. Chem. 277, 1047–1057. 62. Lee, H. , Pettit, G. , and Smith, J. B. (1997) Bryostatin 1 and phorbol ester down-modulate protein kinase C-alpha and -epsilon via the ubiquitiin/ proteasome pathway in human fibroblasts. Mol. Pharmacol. 51, 439–447, 1997 63.

Wertz, S. , Grisham, C. , Cafiso, D. , and Sando, J. J. (1998) Influence of lipid on the structure and phosphorylation of Protein kinase C α substrate peptides. Biochem. J. 330, 1433–1442 44. Bazzi, M. D. and Nelsestuen, G. L. (1987) Association of protein kinase C with phospholipid vesicles. Biochemistry 26, 115–122. 45. Bazzi, M. , Youakim, M. , and Nelsestuen, G. L. (1992) Importance of phosphatidylethanolamine for association of protein kinase C and other cytosolic proteins with membranes.

C. (2001) Structure of the C2 domain from novel protein kinase C epsilon. A membrane binding model for Ca2+-independent C2 domains. J. Mol. Biol. 311, 837–849. 24. Medkova, M. and Cho, W. (1999) Interplay of C1 and C2 domains of protein kinase C-alpha in its membrane binding and activation. J. Biol. Chem. 274, 19,852–19,861. 25. Hurley, J. , Newton, A. , Parker, P. , and Nishizuka, Y. (1997) Taxonomy and function of C1 protein kinase C homology domains. Protein Sci. 6, 477–480. 26. Bolen, E. J.

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