By J. A. Vale, T. J. Meredith (auth.), J. A. Vale MD, MRCP, T. J. Meredith MA, MRCP (eds.)
In the decade, the prevalence of acute poisoning within the constructed international has risen significantly, in order that medical institution admissions from this reason now repre~ despatched an important a part of the paintings load of such a lot scientific devices. the aim of this e-book is to supply an up to date account of the diag nosis and remedy of the entire clinically very important poisons. in the course of the textual content the purpose has been to stress the mechanisms of toxicity - anywhere they're identified - in order that a rational method of remedy will be devised. furthermore, sizeable chapters were dedicated to the psychiatric verify ment of self-poisoned sufferers and to the position of the laboratory. types of presentation were followed. sure themes are mentioned extensive both due to their medical value or simply because contemporary facts became on hand touching on pathophysiology or therapy. by contrast, whilst matters were good defined formerly ordinarily scientific texts, for instance, carbon monoxide poisoning, the dialogue is way extra short and to the purpose. an identical kind has been followed with lately brought medicinal drugs, the place little is understood in regards to the results in overdose. the price of cer tain chapters, particularly these on toxic vegetation and snake bites, has been more suitable via the inclusion of a big variety of color photographs.
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Additional resources for Poisoning Diagnosis and Treatment
5 mE of digoxin and developed heart block, extreme bradycardia and intractable hyperkalaemia. Sinus rhythm was restored within 10 minutes of infusion of 1100 mg of Fab and the serum free digoxin level fell from 20 ng/rnl to less than 1 ng/rnl within an hour of commencement of treatment. 6. A schematic representation of an antibody showing the two antigen-specific Fab fragments, composed of heavy and light chains, and the Fc fragment which confers antigenicity on the antibody molecule itself. of severe digoxin poisoning (see Chapter 16).
AsPiration and lavage Emesis Indications Indications 1. A potentially toxic dose of poison has been ingested. 1. A potentially toxic dose of poison has been ingested. 2. Treatment can be given within four hours of ingestion (longer for salicylates and anticholinergic drugs including tricyclic antidepressants) . 3. Patient unconscious and time of ingestion not known. 4. g. concentrated paraquat solutions or formic acid. Contraindications 1. Poisoning due to petroleum distillates. Sodium chloride.
It is therefore able to protect and reactivate sulphydryl groups in enzyme systems. The alcohol group on the dimercaprol molecule confers water solubility and thereby enhances excretion of the complex from the body. There is a tendency for any chelation complex to dissociate and release toxic metal ions into the circulation; for this reason it is important to maintain a constant excess of the chelating agent. Unfortunately dimercaprol is itself toxic and too great an excess may cause unpleasant side-effects such as nausea, vomiting, hypotension, tachycardia, a burning sensation in the lips, mouth and throat and a feeling of constriction in the throat, chest or hands.