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By Loralie J. Langman, Visit Amazon's Amitava Dasgupta Page, search results, Learn about Author Central, Amitava Dasgupta,

Pharmacogenomics is the root of custom-made drugs with a view to be the medication of the long run. via either decreasing the numbers of difficult drug reactions and bettering using current medications in unique populations, pharmacogenomics represents a true boost on conventional healing drug tracking.

Pharmacogenomics in medical Therapeutics offers an advent to the rules of pharmacogenomics earlier than addressing the pharmacogenomic facets of key healing components corresponding to warfarin treatment, melanoma chemotherapy, remedy with immunosuppressants, antiretroviral remedy, and psychoactive medicines. additionally it is equipment of pharmacogenomic checking out and the pharmacogenomic features of drug–drug interactions.

From a group of professional participants, Pharmacogenomics in scientific Therapeutics is a complete evaluate of the present nation of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and scientific laboratory pros. it's also a advisor for practising clinicians and future health care execs to the fundamental rules of pharmacogenomics, laboratory exams at the moment on hand to assist clinicians, and the long run promise of this constructing field.Content:
Chapter 1 Pharmacogenomics ideas: advent to personalised drugs (pages 1–14): Parvaz Madadi and Gideon Koren
Chapter 2 conventional healing Drug tracking and Pharmacogenomics: Are They Complementary? (pages 15–25): Christine L. H. Snozek, Loralie J. Langman and Amitava Dasgupta
Chapter three Pharmacogenomics point of Warfarin treatment (pages 26–38): Matthew D. Krasowski
Chapter four Pharmacogenetics and melanoma Chemotherapy (pages 39–52): Christine L. H. Snozek
Chapter five Pharmacogenomic issues in Anesthesia and discomfort administration (pages 53–69): Christine M. Formea and Wayne T. Nicholson
Chapter 6 Pharmacogenomics of Immunosuppressants (pages 70–97): Nicolas Picard and Pierre Marquet
Chapter 7 Pharmacogenomics of Cardiovascular medications (pages 98–126): Linnea M. Baudhuin
Chapter eight Pharmacogenomic points of Antiretroviral remedy (pages 127–143): Natella Y. Rakhmanina and John N. van den Anker
Chapter nine Pharmacogenetics of Psychoactive medicinal drugs (pages 144–175): Jorge L. Sepulveda
Chapter 10 Pharmacogenomic elements of inauspicious Drug–Drug Interactions (pages 176–184): Loralie J. Langman and Christine L. H. Snozek
Chapter eleven Microarray know-how and different tools in Pharmacogenomics trying out (pages 185–200): Jorge L. Sepulveda
Chapter 12 Pharmacogenetic trying out within the medical Laboratory surroundings (pages 201–223): Mark P. Borgman and Mark W. Linder

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Golmard, J. , et al. (2010) Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients. Clinical Pharmacology & Therapeutics, 87, 57–64. , et al. (2003) Multivitamin supplements may affect warfarin anticoagulation in susceptible patients. Annals of Pharmacotherapy, 37, 1603–1606. O. (2010) Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases. Pharmacological Therapies, 125, 446–463.

One main mechanism underlying this is reduced synthesis of vitamin Kdependent clotting factors, which in itself leads to increased tendency for bleeding. Additionally, in severe liver failure, CYP enzyme (including 2C9) expression is compromised, leading to decreased clearance of warfarin (91). 1. 1 A summary of the major known factors that affect warfarin dosing. , age, gender, and cigarette smoking), concomitant medications, and genetic variation. The percentages included in parentheses next to some factors are the R2 contribution of these factors to a multiple regression model of warfarin maintenance dosing prediction (82).

1964) Resistance to warfarin in the common rat. Nature, 203, 778. M. (1968) Hereditary resistance to coumarin anticoagulant drugs in man and rat. Annals of the New York Academy of Sciences, 151, 913–931. , et al. Blood,105,645–649. , et al. (2008) Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin. Genetics in Medicine, 10, 139–150. , et al. (2005) Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. New England Journal of Medicine, 352, 2285–2293. , et al.

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