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By William G. Dewhurst (auth.), A. A. Boulton, G. B. Baker, W. G. Dewhurst, M. Sandler (eds.)

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Extra resources for Neurobiology of the Trace Amines: Analytical, Physiological, Pharmacological, Behavioral, and Clinical Aspects

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Biochem. 53, 42-50. A. A. (1981) Deuterium isotope effects on the enzymatic oxidative deamination of trace amines. Biochem. Pharmacol. 30, 3089-3094. A. A. (1982) Deuterium isotope effect on the enzymatic oxidation of dopamine and serotonin. Biochem. Pharmacol. ~, 3697-3698. B. ANALYSIS QUANTIFICATION OF TRACE AMINES AND THEIR METABOLITES BY HIGH RESOLUTION OR METASTABLE ANALYSIS USING DOUBLE FOCUSSING MASS SPECTROMETRY David A. Durden Psychiatric Research Division Cancer and Medical Research Building University of Saskatchewan Saskatoon, Saskatchewan S7N OWO INTRODUCTION During the past 15 years, many methods have been developed for the detection of the trace amines and their metabolites.

One only has to look at the urinary concentrations of phenylacetic acid, m- and p-hydroxyphenylacetic acid and p-hydroxymandelic acid to realise just how misleading such a title can be. It is not my intention in this brief overview to describe what is going to be discussed in much more detail during the various sessions to follow at this conference or what has been written in several recent reviews (Boulton, 1976; 1978a,b; 1979a; Boulton and Juorio, 1982; Durden and Boulton, 1982); rather I am going to skip over the methodological, analytical, distribution, pharmacological, physiological and bioclinical studies in order to draw attention to the emerging field of the behavioural pharmacology of the trace amines, particularly in relation to certain components of spontaneous activity, their probable involvement in the mediation of action of some of the classical monoamines and their possible role as neuromodulators.

And Nasse o. (1865) Beitrag zur Keuntnifs des tyrosins. Liebigs Ann. Chern. 133, 211-216. Trendelenburg U. (1972) Classification of sympathomimetic amines. Handbook Exp. Pharmacol. 33, 336-362. Usdin E. and Sandler 11. (eds) (1976) Trace Amines and the Brain, Marcel Dekker, New York. Wood P. (1982) A selected ion monitoring assay for dopamine and its metabolites using negative chemical ionization. Biomed. Mass Spec. 9, 302-306. H. and Boulton A~A. (1973) Distribution and metabolism of tryptamine in rat brain.

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