Download Multiple Drug Resistance in Cancer: Cellular, Molecular and by James M. Croop (auth.), Martin Clynes (eds.) PDF

By James M. Croop (auth.), Martin Clynes (eds.)

This ebook is an up to date assessment of present wisdom within the box of a number of drug resistance in human melanoma. The literature as much as the center of 1993 is surveyed in expert chapters written by way of varied specialists. issues lined comprise the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; substitute delivery proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; mobile types for MDR in stable tumours and haemopoietic tumours; immunochemical and molecular organic suggestions for detection of MDR-related gene expression; and scientific and pharmacological concepts to bypass resistance. The e-book brings jointly a brand new blend of ways to this critical medical challenge.

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P-glycoprotein is located within the plasma membrane and is thought to act as an energy-dependent drug efflux pump. The multidrug transporter represents a member of the A TP-binding cassette superfamily of transporters (or traffic ATPases) and is composed of two highly homologous halves, each of which harbors a hydrophobic transmembrane domain and a hydrophilic A TP-binding fold. This review focuses on various biochemical and molecular genetic approaches used to analyze the structure, function, and mechanism of action of the multidrug transporter, whose most intriguing feature is its ability to interact with a large number of structurally and functionally different amphiphilic compounds.

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Gill DR, Hyde SC, Higgins CF, Valverde MA, Mintenig GM and Sepulveda FV (1992) Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein. Cell 71: 23-32. Gottesman M and Pastan I (1989) The multidrug resistance transporter, a double-edged sword. J BioI Chern 263: 12163-12166. Greenberger LM, Lothstein L, Williams SS and Horwitz SB (1988a) Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines. Proc Natl Acad Sci USA 85: 3762-3766.

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