Download Mass Spectrometry in Sports Drug Testing: Characterization by Mario Thevis PDF

By Mario Thevis

"This ebook offers an in depth review concerning the mass spectrometry of diverse sessions of therapeutics and brokers proper to doping keep an eye on laboratories, the need of assorted analyzers permitting the detection of low- and excessive molecular weight medicinal drugs in addition to the discrimination among endogenously produced and synthetically derived compounds. common assays together with pattern training, chromatographic separation and mass spectrometric research are awarded highlighting the comprehensiveness of drug checking out in sleek doping keep watch over laboratories"--Provided by means of writer. learn more... content material: heritage of activities drug checking out -- old makes an attempt of synthetic functionality enhancement -- history and cause of doping controls -- dishonest -- future health concerns -- moral matters -- Early detection equipment: probabilities and boundaries of assays with out mass spectrometry -- First functions utilizing chemical and organic ways in horse doping regulate -- First functions utilizing chemical and organic techniques in horse doping keep an eye on -- First functions utilizing chemical methods in human doping keep an eye on -- creation of mass spectrometry to doping keep an eye on research -- First methods and opposed analytical findings -- Progressino of analytical tools -- Mass spectrometry and the checklist of prohibited components and techniques of doping -- standards for the mass spectrometric identity of prohibited compounds -- Low molecular weight analytes -- excessive molecular weight analytes -- smooth mass spectrometers in doping controls: advances and disadvantates of obtainable innovations -- Ionization innovations in regimen doping controls -- Mass analyzers in regimen doping controls -- constitution characterization of low molecular weight aim analytes--electron ionization -- Stimulants -- Narcotics -- Anabolic androgenic steroids -- Unsaturated 3-keto-steroids -- a, ß-saturated ketosteroids -- 3-keto-1,4-diene, 3-keto-4,6-diene, and 3-keto-4,9(11)-diene steroids -- Steroid derivatization -- Selective androgen receptor modulators (SARMs) -- 2-quinolinone-based SARMs -- Hydroxybicyclic hydantoin-derived SARMs -- Diuretics -- Thiazide-derived medicines -- Benzoic acid-derived loop diuretics -- Potassium-sparing diuretics -- ß₂-agonists -- ß-receptor blocking off brokers -- Calcium-channel modulators (RYCALS) -- Carbohydrate-based brokers -- Mannitol -- Glycerol -- Hydroxyethl starch and dextran -- constitution characterization of low molecular weight goal analytes: electrospray ionization -- Stimulants -- Narcotics -- Anabolic androgenic steroids -- z, ß-saturated 3-keto-steroids -- 3-keto-4-ene and 3keto-1-ene steroids -- 3-keto-1,4-diene steroids -- 3-keto-4,6-diene steroids -- 3-keto-4,9-diene steroids -- 3-keto-4,9,1-triene steroids -- Stanozolol -- Selective androgen receptor modulators (SARMs) -- Arylpropionamide-derived SARMs -- Hydroxybicyclic hydantoin-derived SARMs -- 2-quinolinone-derived SARMs -- Diuretics -- Thiazide-derived medicinal drugs -- Benzoic acid-derived loop diuretics -- Potassium-sparing diuretics -- ß₂-agonists -- Calcium-channel modulators (RYCALS) -- Peroxisome-proliferator activated receptor- (PPAR) and adenosine monophosphate activated protein kinase (AMPK) agonists -- Hypoxia-inducible issue (HIF)-stabilizers and sirtuin activators -- HIF-stabilizers -- Sirtuin activators -- ß-receptor blockading brokers -- Glucuronic acid and sulfate conjugates of aim analytes. constitution characterization of excessive molecular weight objective analytes: electrospray ionization -- Human chorionic gonadotrophin (hCG) -- Erythropoietins (EPO) -- Synacthen -- Insulins -- Hemoglobin-based oxygen providers (HBOCs) -- Human progress hormone (hGH) -- Sermorelin (Geref) -- Insulin-like development factor-1 (IGF-1) -- Gonadorelin (LHRH) -- glossy mass spectrometry-based analytical assays -- GC-MS and isotope ratio mass spectrometry -- Stimulants/narcotics -- Anabolic androgenic steroids -- Diuretics -- ß₂-agonists and ß-receptor blockading brokers -- Carbohydrate-based brokers -- LC-MS/MS -- Stimulants/narcotics/ß₂-agonists/ß-receptor blocking off brokers -- Anabolic androgenic steroids/corticosteroids/hormone antagonists and modulators -- protecting brokers (including diuretics) -- Peptide hormones <10kDa together with insulins, synacthen, gonadorelin, IGF-1 -- Hemoglobin-based oxygen providers -- Human chorionic gonadotrophin (hCG) -- barriers and views of mass spectrometry-based tactics in doping regulate research -- Recombinant biomolecules -- Erythropoietin -- Human progress hormone -- Human insulin and IFG-1 -- Unknown compounds -- Profiling of urine and/or blood -- substitute specimens. summary: Mass spectrometry is a big device to represent, establish, and notice enormous quantities of identified and unknown medications. learn more...

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Additional info for Mass Spectrometry in Sports Drug Testing: Characterization of Prohibited Substances and Doping Control Analytical Assays (Wiley - Interscience Series on Mass Spectrometry)

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1962) Studies on human growth hormone. II. The physiological disposition and metabolic 34 154. 155. 156. 157. 158. 159. 160. 161. 162. 163. 164. 165. 166. 167. HISTORY OF SPORTS DRUG TESTING fate of human growth hormone in man. Journal of Clinical Investigation, 41, 262–268. , and Papkoff, H. (1960) Immunochemical investigations of human pituitary growth hormone. Journal of Biological Chemistry, 235: 1038–1042. , and Maingay, D. (1963) Heterogeneity of human growth hormone. Its influence on a radio-immunoassay of the hormone in serum.

A. Davis Company, Philadelphia. 9. World Anti-Doping Agency (2003) The World Anti-Doping Code. pdf. Accessed 02-14-2008. 10. , and Püschel, K. (2008). Damage to health and fatalities from doping. Rechtsmedizin, 18, 177–182. 11. , et al. (2007) Consequences of use of anabolic androgenic steroids. Pediatric Clinics of North-America, 54, 677–690. 12. Prokop, L. (1970) Zur Geschichte des Dopings und seiner Bekämpfung. Sportarzt und Sportmedizin, 21, 125–132. 13. L. (1985) Sudden death in athletes. Annales de Cardiologie et d’Angéiologie, 34, 145–149.

1962) Separation and identification of some sympathomimetic amines by gas chromatography. Analytical Chemistry, 34, 1345–1346. 90. L. (1963) Rapid gas chromatographic method for screening of toxicological extracts for alkaloids, barbiturates, sympathomimetic amines, and tranquilizers. Analytical Chemistry, 35, 356–359. 91. B. (1962) Gas chromatography of sympathomimetic amines. Journal of Pharmaceutical Sciences, 51, 393. 92. B. Separation and identification of sympathomimetic amines by gas-liquid chromatography.

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