By Julia F. Simard Sc.D., Karen H. Costenbader M.D., M.P.H. (auth.), Peter H. Schur, Elena M. Massarotti (eds.)
Often thought of the prototypic autoimmune disorder, Lupus is characterised by way of protean manifestations and impacts quite a lot of organ platforms. regardless of frequent availability of anti nuclear antibody checking out and different technological diagnostic advances, the analysis of lupus could be elusive, tricky, and inexact. remedy of the illness is additionally difficult. Advances in immunology and biotechnology have resulted in a burgeoning international of recent remedies in improvement that provide sufferers the genuine risk of latest cures and physicians and scientists novel insights into the pathogenesis of this advanced immunological ailment. Lupus Erythematosus: scientific evaluate and Treatment summarizes the scientific facets of lupus dealing with the overall clinician within the 21st century. during this precious, functional ebook, the reader will locate introductory chapters relating to normal diagnostic and remedy rules, by way of chapters addressing the lupus-specific organ manifestations. specified subject matters concerning being pregnant and comorbidities also are offered. Written by means of hugely skilled physicians with exact services in lupus, Lupus Erythematosus: medical overview and Treatment is an integral reference for the typical and never so universal difficulties affecting sufferers with lupus.
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Additional resources for Lupus Erythematosus: Clinical Evaluation and Treatment
Selection and interpretation of diagnostic tests and procedures. Principles and applications. Ann Intern Med. 1981;94:557. 25. Calvo-Alen J, Bastian HM, Straaton KV, et al. Identiﬁcation of patient subsets among those presumptively diagnosed with, referred, and/or followed up for SLE at a large tertiary care center. Arthritis Rheum. 1995;38:1475. 26. Smeenk R, Brinkman K, van den Brink H, et al. Antibodies to DNA in patients with SLE. Their role in the diagnosis, the follow-up and the pathogenesis of the disease.
Yurasov S, Wardemann H, Hammersen J, et al. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med. 2005;201(5):703–11. Chapter 3 Diagnosing and Monitoring Lupus Elena M. Massarotti and Peter H. Schur Introduction Making the diagnosis of lupus can be challenging. Patients with SLE are subject to a myriad of symptoms, complaints, as well as inﬂammation that can affect virtually every organ. The most common pattern is a mixture of constitutional complaints with skin, musculoskeletal, hematologic, and serologic involvement.
M. H. Schur 75–100 %, and the positive predictive value is 89–100 %. For antibodies to Sm, the sensitivity is up to 55 % and the speciﬁcity is 58–100 %. Some autoantibodies produced in patients with SLE or other rheumatic diseases tend to be associated with certain clinical settings with a variable degree of sensitivity and speciﬁcity: • Antibodies to ribonucleoprotein (RNP) are associated with SLE, mixed connective tissue disease, rheumatoid arthritis, and scleroderma. • Antibodies to Ro (SS-A) and La (SS-B) are associated with both SLE and Sjögren’s syndrome.