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By G. W. Barendsen, J. J. Broerse and K. Breur (Eds.)

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Extra resources for High-LET Radiations in Clinical Radiotherapy. Proceedings of the 3rd Meeting on Fundamental and Practical Aspects of the Application of Fast Neutrons and Other High-LET Particles in Clinical Radiotherapy, The Hague, Netherlands, 13–15 September 1978

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A U G U S T , p. S H A P I R O and R. B . T H E U S , (1975) The Physics and dosimetry of fast neutrons for radiotherapy. N R L Memorandum, Report 3123, September. C A T T E R A L L , M . , L S U T H E R L A N D and D . K . BEWLEY, (1975) First results of a randomized clinical trial of fast neutrons compared with X or gamma rays in treatment of advanced tumors of the head and neck. Brit. Med. J. 2, 6 5 3 - 6 5 6 . C A T T E R A L L , M . , D . K . BEWLEY and L S U T H E R L A N D , (1977) Second report on results of a randomized clinical trial of fast neutrons compared with X or gamma rays in treatment of advanced tumors of the head and neck.

0 Moderate nausea and vomiting controlled with antiemetics Moderate diarrhea controlled with opiates N o evidence of dehydration. 0 Severe nausea and vomiting not controlled with antiemetics and opiates No evidence of dehydration. 0 Hospitalization required for intravenous feeding and supportive care 46 R, Ornitz et al often delaying the initiation of maintenance chemotherapy. 61. 63. Not a single case of radiation nephritis or radiation hepatitis has been observed when limiting renal dose to 624 rad « 7 and hepatic dose of 936 rad A2 -h7.

Of these, two had a complete response and one patient is still alive apparently free of disease. Seventeen patients with locally advanced pancreatic carcinoma were treated, twelve with combination chemotherapy. The dis­ tinction between partial and complete response is quite subjective, allowing assessment largely in terms of crude survival rate. Additional con­ trolled clinical trials will be required to assess a potential gain factor for pancreatic carcinoma. Sarcomas Twenty-one patients were treated with either bony or soft tissue sarcoma, the majority of which were either of low or unspecified grade.

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