By Jannes Doppenberg, Piet van der Aar
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Extra resources for Dynamics in Animal Nutrition
Natural alternatives to in-feed antibiotics in pig production: Can immunomodulators play a role? Animal 3:1644-1661. , 2006. Nutritional approach to restore impaired intestinal barrier function and growth after neonatal stress in rats. Journal of Pediatrics, Gastroenterology & Nutrition 43: 16-24. , 2006. Neonatal maternal separation causes colonic dysfunction in rat pups including impaired host resistance. Pediatric Research 59: 83-88. , 2007a. Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation.
Johnsonii L. acidophilus L. acidophilus ATCC 4356 L. rhamnosus GG L. reuteri Secreted proteins L. rhamnosus GG L. casei ATCC 334 L. casei ATCC 393 Soluble peptides L. rhamnosus GG L. rhamnosus GG L. plantarum Bacillus subtilis Component2 Signalling3 Effect LTA La1 LTA La10 ? ? ? MAPK, Akt IkB, EGF cytokine (IL-8) release cytokine (IL-8) release anti-apoptotic, antiinflammatory anti-apoptotic p40, p75 p40, p75 p40, p75 Akt, PI3K Akt, PI3K PKC, MAPK epithelial homeostasis cell growth, anti-apoptotic cell growth, anti-apoptotic ?
HSP 70 is more involved in intra-cellular protein chaperoning. g. , 2004). By contrast, duodenal and jejunal 36 Dynamics in animal nutrition Dynamics in animal nutrition Various immunomodulatory cells CD4+ T lymphocytes Various cells (incl. IEC cells) TNFα IL-1β IL-4 IL-6 IL-10 IL-13 TGF-β TEER (-/+) PCP (+/-) TEER (-) PCP (+) TEER (-) PCP (+) TEER (-) PCP (+) Claudin-1 (+) Claudin-2 (-) Protective against barrier and TJ changes induced by IFNγ ? Claudin-2 (-) Occludin (-) TJ strand numbers and depths (-) ERK or PKC Akt ?