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By J. Crooks, I.H. Stevenson

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H. Powers), Saunders, London, pp. 10-43 Smith, G. , Walford, R. L. and Mickey, M. R. (1973). Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their FI hybrids. J. natn. , 50,1195-213 Storer, J. B. (1966). Longevity and gross pathology at death in 22 inbred mouse strains. J. , 21, 404-9 Walford, R. L. (1969). The Immunologic Theory of Aging, Munksgaard, Copenhagen Walford, R. L. (1976). Letters to the Editor. When is a mouse 'old'? J. , 117,352-53 3 Criteria for the design of an animal-holding facility for ageing animals as illustrated by the Wolfson Laboratory for Research in Gerontology J.

In this design, rats are offered food ad libitum but of three different compositions with respect to protein level. The result is that rats choose varying proportions of dietary protein throughout their lives. Viewing all of these experiments as a whole, and bearing in mind the problems of protein-energy interactions, leaves one with the strong impression simply that any treatment which effectively increases lifespan will also reduce maximum body weight and in most cases inevitably also will reduce the velocity of early growth.

1975). Unlimited division potential of pre-cancerous mouse mammary cells after spontaneous or carcinogen induced transformation. Fedn. Proc. Fedn. Am. Soc. , 34,64-7 Drews, U. and Drews, U. (1977). Regression of mouse mammary gland anlagen in recombinants of lfm and wild-type tissues: testosterone acts via the mesenchyme. , Evans, I. H. and Wilkie, D. (1976). Primary antimitochondrial activity of carcinogens in Saccharomyces cerevisiae. In Genetics and Biogenesis of Chloroplasts and Mitochondria (ed.

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