Download Drug Delivery Nanoparticles Formulation and Characterization by Yashwant Pathak, Deepak Thassu PDF

By Yashwant Pathak, Deepak Thassu

Discover the elemental ideas of drug supply formula and characterization. Nanoparticulate Drug supply platforms II provides key features of nanoparticulate approach improvement for numerous healing purposes and gives complex equipment used to dossier for regulatory approval. This accomplished consultant good points: a hundred top of the range pictures strategy Analytical options (PAT) utilized in production Nanoparticulate Drug supply platforms (NDDS) in-vitro and in-vivo assessment of NDDS purposes of novel options utilized in formula improvement and characterization, similar to microscopic and nonmicroscopic strategies

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Extra info for Drug Delivery Nanoparticles Formulation and Characterization (Drugs and the Pharmaceutical Sciences, 191)

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Lu H, Li B, Kang Y, et al. Paclitaxel nanoparticle inhibits growth of ovarian cancer xenografts and enhances lymphatic targeting. Cancer Chemother Pharmacol 2007; 59:175–181. 71. Hatakeyama H, Akita H, Kogure K, et al. Development of a novel systemic gene delivery system for cancer therapy with a tumor specific cleavable PEG lipid. Gene Ther 2007; 14:68–77. 72. Myc A, Majoros IJ, Thomas TP, et al. Dendrimer-based targeted delivery of an apoptotic sensor in cancer cells. Biomacromolecules 2007; 8:13–18.

Later, the organic solvent containing the dissolved polymer and the drug is emulsified in an aqueous surfactant solution (usually with PVA as a stabilizing agent) by using a high-speed homogenizer. Water is subsequently added under constant stirring to the o/w emulsion system, thus causing phase transformation and outward diffusion of the solvent from the internal phase, leading to the nanoprecipitation of the polymer and the formation of colloidal nanoparticles. Finally, the solvent can be eliminated by vacuum steam distillation or evaporation.

Enhanced intratumoral uptake of quantum dots concealed within hydrogel nanoparticles. Nanotechnology 2008; 19:485102. 81. Vihola H, Laukknen A, Tenhu H, et al. Drug release characteristics of physically crosslinked thermosensitive poly(N-vinyl caprolactum) hydrogel particles. J Pharm Sci 2008; 97:4783–4793. 82. Baroli B. Hydrogels for tissue engineering and delivery of tissue inducing substances. J Pharm Sci 2007; 96:2197–2223. Recent Developments in Nanoparticulate Drug Delivery Systems 15 83.

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