By A. R. Prévot (auth.), Bernard Halpern (eds.)
In his advent to the Ciba starting place Symposium on "Immunopotentia tion," Sir Peter Medawar said that, "for the previous two decades the keep an eye on of the immune reaction has been almost equated to immunosuppression as the nice aim of utilized immunology has been the transplantation of tissues," and that, "with the invention of tumor immunity-the point of interest of immuno logical regulate has replaced from immunosuppression to immunpotentiation and correspondingly the good prize of utilized immunology has develop into the preven tion and regulate of malignant growth." Corynebacterium parvum is now univer sally famous as being the main powerful almost immediately recognized immunopotentiator. C parvum is on the middle of just about all papers awarded at this convention and it's been analyzed from a variety of viewpoints: taxonomy, pharmacology, immunopotentiation, stimulation of host resistance to tumor invasion in experi psychological types and in human therapeutics. just about all info stated during this quantity are unique and lately received. The discussions have been spontaneous, stimulating, and hugely enriching, and the consequences already tested and re ported listed below are in lots of respects particular. Discussions on the convention printed many different elements which require extra exploration. Nonspecific immunopotentiation has strongly penetrated into immunology, immunopathology, and, lately, oncology. certainly, this zone of study will witness vital advancements within the close to destiny. This publication deals the 1st synthesis of almost immediately to be had wisdom and emphasizes destiny prospects.
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Additional resources for Corynebacterium Parvum: Applications in Experimental and Clinical Oncology
And Downs, W. G. (1966). Use of Sarcoma 180 T/G to prepare hyperimmune ascitic fluid in the mouse. J. Immunol. 96:676. Westphal, O. and Jann, K. (1964). Methods in Carbohydrate Chemistry, Vol. V, p. 83, (R. L. Whistler and M. L. ), Academic Press, New York and London. Wheat, R. W. (1966). Methods in Enzymology, Vol. VIII, p. 60, (E. F. Neufeld and V. ), Academic Press, New York and London. 4 Study on Soluble Substances Extracted from Corynebacterium parvum P. JOLLES, D. MIGLIORE-SAMOUR, M. KORONlZIS, F.
In this situation, the word "toxicity" does not have a real pharmacological meaning, because we are dealing with a biological substance, which is stimulating biological functions. It is puzzling that a stimulatory effect on biological functions may lead to illness and weakness, and sometimes to death. What are the mechanisms involved? This is an important question which has not been answered. Part II Toxicology, Pharmacology, Adjuvant Properties 3 The Nature of the Active Principle of Corynebacterium parvum C.
N. , and Mouton, D. (1966). Inhibition of tumor growth by administration of killed Corynebacterium parvum. ) 212:853. Halpern, B. , Lorinet, A. , and Rabourdin, A. (l973a). Action inhibitrice du Corynebacterium parvum sur Ie developpement des tumeurs malignes syngeneiques et son mecanisme. C. R. Acad. Sci. 276: 1911. , Lorinet, A. , and Isac, R. (l973b). Corynebacterium parvum, a potent immunostimulant in experimental infections and in malignancies. Immunopotentiation. Excerpta Med. Sect. 18:217.