By Manjula K. Gupta PhD (auth.), Tommaso Falcone, William W. Hurd (eds.)
Clinical Reproductive medication and Surgery bargains a succinct review of either the clinical and surgical administration of reproductive issues, in addition to insurance of linked imaging modalities. The booklet comprises chapters on significant reproductive endocrinology and infertility concerns similar to polycystic ovary syndrome and amenorrhea, administration of endometriosis and fibroids (including interventional radiology), imaging modalities reminiscent of ultrasonography and sonohysterography, renovation of fertility, and recurrent being pregnant loss. citizens, fellows, and practitioners attracted to reproductive endocrinology and infertility will locate this centred and functional textual content invaluable.
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Additional info for Clinical Reproductive Medicine and Surgery: A Practical Guide
Presence of transforming growth factor-alpha messenger ribonucleic acid (mRNA) and absence of epidermal growth factor mRNA in rat ovarian granulosa cells, and the effects of these factors on steroidogenesis in vitro. Biol Reprod. 1993;48(5):1071–81. 146. Adashi EY, Resnick CE, Croft CS, May JV, Gospodarowicz D. Basic fibroblast growth factor as a regulator of ovarian granulosa cell differentiation: a novel non-mitogenic role. Mol Cell Endocrinol. 1988;55(1):7–14. 147. McAllister JM, Byrd W, Simpson ER.
Antiestrogens and ER Compounds with antiestrogenic activity can be classified into two categories: one with pure antiestrogenic activity and others with both agonist and antagonist properties. Tamoxifen—an antiestrogen that is used both as chemopreventive agent and as hormonal therapeutic agent for breast cancer—inhibits ER action . Paradoxically, tamoxifen acts as an estrogen in uterine tissue, and this tissue-specific estrogenic effect is the reason why prolonged tamoxifen therapy increases the risk of uterine 1 Ovarian Hormones: Structure, Biosynthesis, Function, Mechanism of Action, and Laboratory Diagnosis 19 Fig.
HSP90 heat shock protein; HRE hormone response element; C-A coactivators. Reproduced with permission from Gupta MK, Chia SY. In: Hurd WW, Falcone T, eds. Clinical reproductive medicine and surgery. St. Louis, MO: Mosby/Elsevier; 2007 heterodimers with RXR. These interactions may serve to modulate the amplitude of the transcriptional response to the ligand. Most of the early knowledge about steroid hormone mechanism of action has been derived from in vitro and in vivo binding studies that used radiolabeled estradiol as a ligand .