By Dieter Kleinknecht, George A. Porter (auth.), M. E. De Broe, G. A. Porter, W. M. Bennett, G. A. Verpooten (eds.)
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Additional resources for Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals
G. vinblastine, vincristine, colchicine, cyclosporin analogues) from renal proximal cell [58-60]. Pglycoprotein transport mechanism differs from the proton/organic cation exchanger since it does not transport tetraethylammonium [52, 60], and vinblastine, a substrate of P-glycoprotein, is not exchanged against protons in pig brush border membrane vesicles . Also photoaffinity labelling studies suggest that the two transport proteins are different . Since many substrates of the P-glycoprotein system are also transported by the proton/organic cation exchanger, it is often difficult to clearly distinguish between the two systems at the functional level.
Clin Pharmacokin 1987; 13: 334-43. Bowman RH. Renal secretion of [35S]furosemide and its depression by albumin binding. Am 1 Physiol 1975; 229: 93-8. Koschier Fl, Acara M. Transport of 2,4,5-trichloro- 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 83. phenoxyacetate in the isolated, perfused rat kidney. 1 Pharmacol Exp Ther 1979; 208: 287-93. Webb DE, Edwards RM, Grantharn 11. Dependence of proximal tubule p-aminohippurate secretion on serum proteins and metabolic substrates.
15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. albumin blunts the response to furosemide - a mechanism for diuretic resistance in the nephrotic syndrome. J Pharmacol Exp Ther 1990; 252: 1097-101. Kirchner KA, Voelker JR, Brater DC. Binding inhibitors restore furosemide potency in tubulc fluid containing albumin. Kidney Int 1991; 40: 418-24. Weiner IM. Organic acids and bases and uric acid. The Kidney: Physiology and Pathophysiology. Seldin DW, Giebisch G, editors. Raven Press Ltd, New York 1985: 1703-24.