Download Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals by Dieter Kleinknecht, George A. Porter (auth.), M. E. De Broe, PDF

By Dieter Kleinknecht, George A. Porter (auth.), M. E. De Broe, G. A. Porter, W. M. Bennett, G. A. Verpooten (eds.)

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Additional resources for Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals

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G. vinblastine, vincristine, colchicine, cyclosporin analogues) from renal proximal cell [58-60]. Pglycoprotein transport mechanism differs from the proton/organic cation exchanger since it does not transport tetraethylammonium [52, 60], and vinblastine, a substrate of P-glycoprotein, is not exchanged against protons in pig brush border membrane vesicles [51]. Also photoaffinity labelling studies suggest that the two transport proteins are different [61]. Since many substrates of the P-glycoprotein system are also transported by the proton/organic cation exchanger, it is often difficult to clearly distinguish between the two systems at the functional level.

Clin Pharmacokin 1987; 13: 334-43. Bowman RH. Renal secretion of [35S]furosemide and its depression by albumin binding. Am 1 Physiol 1975; 229: 93-8. Koschier Fl, Acara M. Transport of 2,4,5-trichloro- 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 83. phenoxyacetate in the isolated, perfused rat kidney. 1 Pharmacol Exp Ther 1979; 208: 287-93. Webb DE, Edwards RM, Grantharn 11. Dependence of proximal tubule p-aminohippurate secretion on serum proteins and metabolic substrates.

15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. albumin blunts the response to furosemide - a mechanism for diuretic resistance in the nephrotic syndrome. J Pharmacol Exp Ther 1990; 252: 1097-101. Kirchner KA, Voelker JR, Brater DC. Binding inhibitors restore furosemide potency in tubulc fluid containing albumin. Kidney Int 1991; 40: 418-24. Weiner IM. Organic acids and bases and uric acid. The Kidney: Physiology and Pathophysiology. Seldin DW, Giebisch G, editors. Raven Press Ltd, New York 1985: 1703-24.

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