By R. S. Reneman, P. A. J. Janssen (auth.), Prof. Dr. med. A. Doenicke (eds.)
The query tips to result in basic anaesthesia without difficulty has been requested many times by means of anaesthetists and pharmacologists. P. A. JANSSEN constructed etomidate and released this substance in 1971 as "a powerful short-acting and comparatively atoxic intravenous hypnotic agent in rats". In 1974 after a number of years of experimental and medical trial the barbiturate-free hypnotic etomidate (soon advertised as Hypnomidate) used to be brought to varied auditors on the get together of the IV. eu Congress of Anaesthesiologists in Madrid. because the authors prolonged their essays, the reality of the current e-book is given. the belief mentions the recent resolution of etomidate base in 35 % propylene glycol. it's anticipated that the disadvantageous results - venous soreness in the course of injection and linked involuntary muscle stream- will principally be eradicated through the use of the hot formulation of etomidate after premedication of fentanyl. Mlinchen, August 1977 Alfred DOENICKE desk OF CONTENTS The Experimental Pharmacology of Etomidate, a brand new powerful, Short-Acting Intravenous Hypnotic (R. S. RENEMAN and P. A. JANSSEN) •. . . . •• 1 Protein Binding of Etomidate (G. A. MANNES and A. DOENICKE) ••••. . . 6 The impact of Intra-Arterial Injection of Etomidate and Thiopental at the Skeletal Muscle- and Arterial Wall-Structures (R. S. RENEMAN, F. VERHEYEN, R. KRUGER, W. VAN GERVEN and M. BORGES) . . •. . •• nine interplay among Etomidate and the Antihypertensive brokers Propanolol andoC-Methyl-Dopa (R. S. RENEMAN, W. VAN GERVEN and R. KRUGER) ••. •. . . 15 Teratogenicity of Etomidate (A. DOENICKE and M. HAEHL) •. ••. •.