Download Boron Neutron Capture Therapy: Toward Clinical Trials of by E. D. Hondros (auth.), Detlef Gabel, Ray Moss (eds.) PDF

By E. D. Hondros (auth.), Detlef Gabel, Ray Moss (eds.)

The ecu Collaboration on Boron Neutron catch remedy (BNCT), conceived in 1987 and winning in 1989 in gaining monetary aid as a Concerted motion during the clinical and healthiness study Programme of the fee ofthe eu groups (CEC) in Brussels, thought of it an opportune second to carry its annual Plenary assembly on 18-20 Septem­ ber 1991 as a world Workshop entitled "Towards scientific Trials of Glioma with BNCT". The heritage to this attention was once motivated by way of the world-wide resurgence ofinterest in NCT over the past 2 many years and by way of the exemplifica­ tions on the Fourth foreign Symposium on Neutron seize remedy for melanoma held in Sydney in December 1990, the place it used to be strongly indicated that in the subsequent 2 years scientific trials will be began either in Europe and the us. specifically on the excessive Flux Reactor of the Joint learn Centre of the CEC at Petten within the Netherlands, an epithermal neutron beam designed and put in in the summertime of 1990 lately turned operable at complete reactor strength. an intensive sequence ofexperiments, together with the nuclear and radiobiological characterisation of the beam and a fit tissue tolerance examine on canine has begun and has the purpose to outline the preconditions for medical trials onpatients with Grade III/IV glioma. although, as with every different new treatment modality, it needs to be demon­ strated that BNCT is secure for the sufferer and has an inexpensive likelihood of being a good therapy.

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Extra info for Boron Neutron Capture Therapy: Toward Clinical Trials of Glioma Treatment

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In: Progress in Neutron Capture Therapy for Cancer. , Plenum Press, New York 63-66 (1992). Gabel, D. Approach to boron neutron capture therapy in Europe: goals of a European collaboration on boron neutron capture therapy. In: Proc. of the 2nd Eur. Part. Ace. , Nice. Editions Frontieres, Gif-surYvette, 283-285 (1990). P. High flux materials testing reactor Petten, characteristics of the facilities and standard irradiation devices. EUR 5700 EN (1986/87). Moss, RL. Progress towards boron neutron capture therapy at the high flux reactor Petten.

40 Moss Table 1 Programme of experiments for the healthy tissue tolerance study on the canine brain Single fraction mean blood lOB cone. 25cm)[Gy] number of dogs 25 15 19 23 5 5 5 50 23 27 31 5 5 5 Four fractions 25 15 19 23 5 5 5 Healthy Tissue Tolerance Studies For the treatment of patients with malignant glioma, and from the healthy tissue tolerance studies in dogs performed at the BMRR, it is evident that the tissue at risk is not the skin but the normal brain. As depicted in Fig. 4, the peak physical dose for an epithermal beam occurs at 2-3 cm depth, Le.

The contribution of the "pseudo-particle" to the tally at the detector position is then given by an expression of the form R ~(E) W p(E) exp[- f ~t(s,E)ds) o where W is the particle weight, p is the probability of scattering towards the tally position and R is the distance between the event and the tally position. Therapy position Figure 1. Model geometry used for MNCP calculations. 51 Physics calculations for HFR liquid argon (1500) water shutter (400) sulphur (50) dimensions in mm Figure 2. As built filter configuration.

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