Download Alzheimer’s Dementia: Dilemmas in Clinical Research by Robert Katzman (auth.), Vijaya L. Melnick, Nancy Neveloff PDF

By Robert Katzman (auth.), Vijaya L. Melnick, Nancy Neveloff Dubler (eds.)

The nationwide Institute on getting older (NIA) has traditionally been fascinated by the security of human matters. In July 1977, the NIA backed a gathering to replace and complement consultant­ strains for shielding these partaking in Federal learn seasoned­ jects. even if the elemental instructions have been in influence due to the fact that 1966, it have been overlooked to incorporate the aged as a weak inhabitants. In November 1981, the NIA geared up a convention at the moral and felony matters relating to knowledgeable consent in senile dementia instances. the current quantity bargains the most recent and top pondering on Alzheimer's Dementia to have emerged from the conversation that was once first embarked upon on the NIA assembly. certainly, the problems and issues it treats now appear much more appropriate than they seemed traditionally a result of tremendously larger understanding locally of the complete spectrum of difficulties Alzheimer's sickness confronts us all with. Our curiosity and quandary is either humanitarian and self­ serving. basically older humans needs to be protected against in­ applicable study and cautious cognizance needs to be paid to the situations lower than which examine is performed on these older people who've given whatever below complete consent. it truly is both important, besides the fact that, for the learn company to be secure in order that trendy aged and people of the long run can enjoy the end result of research.

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Additional info for Alzheimer’s Dementia: Dilemmas in Clinical Research

Example text

Henry Beecher6 reviewed the literature on this subject; in his conclusion he suggests that 44 Robert J. Levine consent might not be either the only or the most important issue7 An even greater safeguard for the patient than consent is the presence of an informed, able, conscientious, compassionate, responsible investigator, for it is recognized that patients can, when imperfectly informed, be induced to agree, unwisely, to many things. A considerable safeguard is to be found in the practice of having at least two physicians involved.

Regardless of how they had assessed the magnitude of their own memory problem, patients' recognized that their spouses did not have significant problems in this area. Similarly, patients and spouses were in complete agreement with respect to the absence of "a sense of confusion or loss of orientation," or difficulties with recent memory on the part of the spouse. Hence, patients appeared to continue to display insight with respect to their spouses' status throughout the course of the illness studied.

Clinical Symptoms Accompanying Progressive Cognitive Decline and Alzheimer's Disease Relationship to "Denial" and Ability to Give Informed Consent Barry Reisberg, Betty Gordon, Martin McCarthy, and Steven H. Ferris Introduction Alzheimer's disease patients suffer from significant mental decline, and the capacity of these patients to provide "informed" consent can appropriately be questioned. Emotional changes accompany cognitive deterioration in the Alzheimer's patient, and further confound the patient's ability to make "reasoned" judgments about participation in research protocols.

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